pipemidic acid will enhance the degree or impact of caffeine by influencing hepatic enzyme CYP1A2 metabolism. Small/Significance Unfamiliar.lorlatinib will lower the extent or result of ergotamine by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Stay clear of or Use Alternate Drug. Avoid use of lorlatinib with CYP3A substrates, where minim